The potential role of phytocannabinoids and the endocannabinoid system (ECS) in confining malignant tumours is among the most discussed topics in the field of medical cannabis.
There are countless anecdotes from patients and even clinical studies (usually small ones) about the effect of cannabinoids on controlling different types of cancer. Many patients also believe that cannabis and its derivatives are effective tools for fighting against cancer. Hence, many cancer patients want to use cannabis for treating their disease.
The state of evidence
It should be noted that there is not enough clinical evidence about the efficacy of cannabinoids on cancer in humans, however, there is plenty of evidence from preclinical studies indicating that cannabinoids and ECS can potentially play a role in treating cancers.
A review by Dr. Hinz and Dr. Ramer published in the British Journal of Pharmacology has summarized the current state of evidence about the interactions (and possible therapeutic effects) between the ECS and tumours as the followings:
Source: Hinz B, Ramer R. Anti-tumour actions of cannabinoids. Br J Pharmacol. 2019;176(10):1384-1394.