CBN or cannabinol is a non-enzymatic oxidative by-product of THC.
It has a lower affinity for CB1 and CB2 receptors compared to THC (10% of the activity of Δ9-THC at the CB1 receptors).
CBN has been promoted to assist patients that are suffering from insomnia but this claim has not been substantiated by any clinical trials.
Research by Musty et al., reported that oral ingestion of 50 mg CBN did not induce dizziness or drowsiness in human subjects.
“It appears that CBN increases the effect of delta9-THC on some aspects of physiological and psychological processes, but that these effects are small and cannot account for the greater potency which has been reported when plant material is used”.
As the result of the low affinity of CBN to cannabinoid receptors and limited available evidence, CBN shall not be claimed to be a sedative.
Adequate clinical trials focused specifically on the sedative effects of CBN are required to further evaluate potential other mechanisms that may be responsible for reported anecdotal claims by users.
- Health Canada. (2018). Information for Health Care Professionals: Cannabis (marihuana, marijuana) and the cannabinoids. Ottawa: Health Canada.
- Merzouki A, Mesa JM. Concerning kif, a Cannabis sativa L. preparation smoked in the Rif mountains of northern Morocco. J Ethnopharmacol. 2002;81(3):403-406. doi:10.1016/s0378-8741(02)00119-8.
- Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol 2008 01;153(0007-1188; 0007-1188; 2):199-215.
- Izzo AA, Borrelli F, Capasso R, Di M,V, Mechoulam R. Non-psychotropic plant cannabinoids: New therapeutic opportunities from an ancient herb. Trends Pharmacol Sci 2009 10;30(1873-3735; 0165-6147; 10):515-27.
- Evans FJ. Cannabinoids: the separation of central from peripheral effects on a structural basis. Planta Med. 1991;57:S60–S67.
- Musty RE, Karniol IG, Shirikawa I, Takahashi RN, Knobel E. Interactions of delta-9-tetrahydrocannabinol and cannabinol in man. In: Braude MC, Szara S, editors. The Pharmacology of Marihuana. Vol. 2. New York: Raven Press; 1976. pp. 559–563.